CREST Projects

In spring 2011, the first group of CREST students completed a variety of modeling projects. Several focused on designing drugs to fit in the active site of a protein involved in a cell signaling cascade. Others focused on using a homology model to elucidate the structure of an as yet uncharacterized protein. Some focused on desgning a model that would inform ongoing laboratory research. And at least one focused on developing a model and poster that can be used directly in the classroom.

Posters and oral presentations of projects were given at the 2011 CREST Research and Teaching Symposium at MSOE on April 30, 2011.

Symposium Program (arranged to create a booklet if printed double-sided)

Topics

• Bacterial RNA Polymerase: New Insights on a Fundamental Molecular Machine

  • Proteopedia Page: Beta-Prime Subunit of Bacterial RNA Polymerase

• Conserved through the Ages: GATA-1 and Friend of GATA-1 (FOG-1) Interactions with DNA

• Major Histocompatibility Complex — Class I HLA-A2 and Presentation of HERPES Viral Peptides

• Modeling and Inhibition of VEGF-C/VEGFR2 Active Site
• C-Src Kinase Inhibition: A Promising Route in Kidney Cancer Treatment
• Drug Design for Inhibition of Extracellular Signal-Regulated Kinase 2 (ERK2)
• The Importance of Understanding DUSP5 for Angiogenesis Prevention

• Proposing Ligands and an Active Site in NgBR for Cancer Treatment

• Design of Soluble Epoxide Hydrolase Inhibitors as Drug Leads

• β-Catenin: An Essential Player in Both Cell-Cell Adhesion and Wnt Transcriptional Regulation

• Cdc42 Interacting Protein 4 (CIP4) Involvement in Endocytosis and Membrane Protrusion