Jumbled Jmols

Jumbled Jmols are designed to show two structures: one correctly folded and one incorrectly folded, due to amino acids being switched around, or "jumbled". Based on observations of where polar and hydrophobic residues are positioned in the proteins, the user must determine which of the two is the real structure.

• Ribonuclease
• Myoglobin
• Lysozyme
• Insulin

Helpful Hints

If you are unfamiliar with the basic principles of chemistry involved in protein folding, we suggest you start with the tutorial "Basic Principles of Chemistry that Drive Protein Folding". Hydrophobic residues are colored yellow (like chicken fat) when you click the 'hydrophobicity' radio button; polar sidechains have blue nitrogen atoms and red oxygen atoms. In addition to selecting various ways of displaying the features of the protein, you can zoom in with a click and drag of the left mouse button.

Answer Key

If you wish to use the Jumbled Jmols as an assessment tool and want an answer key, contact Margaret Franzen at franzen@msoe.edu.