Student Programs
MAPS Teams
Modeling a Protein Story
Science Olympiad
Protien Modeling Event
Teacher Programs
Development Courses
Regional Workshops
Learning Resources
Lending Library Modeling Resources 3D Molecular Designs

What's New From the CBM?

Virtual Webinar Series

Posted 12-14-2021

One positive outcome of the ongoing COVID19 pandemic is that we have been forced to explore the use of digital technology to engage teachers in professional learning experiences. As it turns out, we have been surprised by the enthusiastic acceptance of this type of learning by our teachers. While we have always believed that our modeling approach to education is best experienced during in-person summer workshops at the CBM, we now acknowledge that professional learning is not a one-size-fits-all proposition. In-person workshops can be intense, chaotic, exciting,. . . and expensive. But for others, especially those with young families, in-person summer workshops can be stressful and simply impossible.

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Nobel Winning Science

Posted 12-6-2021

The Divine Savior Holy Angels SMART Team worked with two graduate students (Andy Weyer and Katherine Zappa) in Cheryl Stucky’s lab at the Medical College of Wisconsin to create a model of David Julius’ recently reported structure of the pain receptor, TRPVI. We made an extra copy of this model and the SMART Team sent the model to Dr. Julius, along with a letter telling him how much they enjoyed working on this modeling project. That model and the accompanying letter prompted a return Thank You letter from Dr. Julius to the Team

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A New Antibody MAPS Module

Posted 1-6-2021

This new MAPS Module will focus on antibodies and their role in our immune system. With everyone’s current focus on a coronavirus vaccine, we thought this would be a timely topic. There are many fascinating stories of current research involving antibodies that your students can explore.

An obvious choice would be the structure of an antibody binding to a coronavirus protein. We will highlight one fascinating story involving a synthetic biology approach to create a nanobody (single-domain antibody) that locks down the coronavirus spike protein into an inactive conformation.

This paper describes our work over the past twenty years. Check it out, and see how you relate to various aspects of our program!

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What are Physical Models?

The invisible world of molecules becomes real when students hold physical models in their hands. Models function as thinking tools that stimulate questions and are a key component of the Next Generation Science Standards.

The MSOE Center for BioMolecular Modeling uses 3D Printing Technology to create physical models of protein and molecular structures. They are designed using the molecular Visualization software Jmol and then exported as 3D files.

What Teachers and Students are Saying About the CBM

"Models give the students an opportunity to discover on their own, rather than having you tell it to them."

"These curriculum modules tie what seems like a really abstract idea--some little change in a molecule you can’t even see—to their own health. That’s really compelling. This stuff isn’t in any textbook."

"The fact that they were so teacher-focused was refreshing."

"The CBM staff let us be learners, and they respected us."

"Watching the CBM staff, who are masters, and being given these models is wonderful. Now we have powerful knowledge and powerful examples that we can put in our kids’ heads. I’m so excited for the school year to start, I don’t want to have to wait two months!"

"It was an amazing workshop. Foundational pieces of biology are woven through these stories."

"It really opened up science to me as a student. Science isn't sitting in a classroom learning about rocks its about being in a lab doing research alongside your mentor."

The [MAPS] Team program has taught me the importance of actively participating in the scientific community, being professional, and having the ability to take something complex and put it into simpler yet accurate terms."

"This program has opened my eyes to an entirely new career field. I have learned so much through this experience and I am extremely grateful that I have experienced this."

Selected Publications

Baeten, J., Munzenmaier, D., Vogt, G., Hoelzer, M. and Herman, T (2020) A Strategy for Sustained Outreach in the Molecular Biosciences. J. STEM Outreach Vol 3, Issue 3

Goodsell, D., Franzen, M. and Herman, T. (2018) From Atoms to Cells: Using Mesoscale Landscapes to Construct Visual Narratives. J. Mol. Biol. 430(21): 3954-3968

Harris, Michelle A., Peck, Ronald E., Colton, Shannon, Morris, Jennifer, Neto, Elias Chaibub and Kallio, Julie. 2009. A combination of hand-held models and computer imaging programs helps students answer oral questions about molecular structure and function: a controlled investigation of student learning. Cell Biol. Ed. 8(1):29-43

Herman, Tim, Colton, Shannon and Franzen, Margaret. 2008. Rethinking Outreach: Teaching the Process of Science through Modeling. PLoS Biology 6(4):e86

Herman, T., Morris, J., Colton, S. Batiza, A., Patrick, M., Franzen, M. and Goodsell, D.S. 2006. Tactile Teaching: Exploring Protein Structure/Function using Physical Models. Biochem. Molec. Biol. Educ. 34:247-254.

Bain, G., Yi, J., Beikmohamadi, M., Herman, T. and Patrick, M. 2006. Using physical models to teach concepts of biochemical structure and structure depiction in the introductory chemistry laboratory. J. Chem. Educ. 83(9):1322-1324. Supplements.

Roberts, J.R., Hagedorn, E., Dillenburg, P., Patrick, M. and Herman, T. Physical models enhance molecular three-dimensional literacy in an introductory biochemistry course. Biochem. Molec. Biol. Educ. 33(2):105-110. 2005

Put Your Lab in a Different Class. Sally Goodman, Nature 420, 12-14 (2002)

Images of Anthrax: A Team Approach. Jon Knopp, Chem Matters, December 2002, pages 4-6

Models of Excitement: Teachers use rapid prototyping to build protein structures. Toni Shears, HHMI Bulletin June 2002, pages 46-47